---
title: "Hypofractionation: Fewer, Higher-Dose Radiation Sessions | 5D Cancer Services"
description: "Hypofractionated radiation therapy delivers a higher dose per treatment in fewer sessions. Adaptive hypofractionation on the Akesis Gemini 360 in St. George, Utah finishes most courses in 5–15 visits instead of 20–45."
canonical: https://www.5dcancerservices.com/treatments/hypofractionation
route: /treatments/hypofractionation
type: page
lastUpdated: 2026-06-01
keywords: ["adaptive radiotherapy", "Akesis Gemini 360", "5D Cancer Services", "St. George Utah", "radiation oncology", "hypofractionation", "hypofractionated radiotherapy", "5-fraction", "shorter radiation course"]
---

# Hypofractionation: Fewer, Higher-Dose Radiation Sessions | 5D Cancer Services

> Hypofractionated radiation therapy delivers a higher dose per treatment in fewer sessions. Adaptive hypofractionation on the Akesis Gemini 360 in St. George, Utah finishes most courses in 5–15 visits instead of 20–45.

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# Spatially Fractionated Radiation Therapy (SFRT / LATTICE)

Spatially fractionated radiation therapy — sometimes called LATTICE radiotherapy — deposits a 3D lattice of high-dose 'peaks' inside a tumor while keeping the surrounding rim at a safer dose. It is most commonly used for bulky, radioresistant, or previously-treated tumors.

Quick summarySFRT (LATTICE) is a specialized adaptive technique that places a heterogeneous pattern of high-dose vertices inside a bulky tumor. It is used at 5D Cancer Services for select bulky, radioresistant, or re-irradiation cases on the Akesis Gemini 360.

- Most useful for tumors ≥ ~6 cm or those resistant to standard radiation
- Delivers a 3D lattice of high-dose 'vertices' separated by lower-dose valleys
- Often combined with conventional fractionated radiation as a 'boost'
- Considered for select re-irradiation cases when standard re-treatment isn't safe
- Plan reviewed jointly by radiation oncology, medical physics, and dosimetry
- Decision is highly individualized — eligibility determined at consultationLast reviewed: 2026-05-12

## What is SFRT?

Spatially fractionated radiation therapy intentionally creates a non-uniform dose inside a tumor: small high-dose 'vertices' (peaks) are arranged in a 3D lattice, separated by lower-dose 'valleys.' This pattern produces a strong tumoricidal and immune-stimulatory effect at the peaks while the lower-dose valleys help limit damage to nearby healthy tissue.

SFRT is sometimes referred to historically as GRID therapy (its 2D predecessor) or LATTICE radiotherapy (the modern 3D variant).

## Who SFRT is considered for

- Large, bulky tumors (commonly ≥ 6 cm in greatest dimension)
- Sarcomas and other radioresistant histologies
- Tumors that have not responded to prior radiation
- Select re-irradiation cases where conventional retreatment exceeds tolerance
- Symptomatic, debulking-style palliation when surgery isn't an option

## What to expect

SFRT is typically delivered as a single high-dose treatment combined with a follow-on course of conventional fractionated radiation. Each treatment session is painless and outpatient. Because SFRT is highly individualized, the radiation oncologist will walk through whether your case is appropriate and what the expected dose distribution will look like.

## Important considerations

SFRT is a specialized technique and is not appropriate for every tumor. The decision to use SFRT is made jointly by radiation oncology, medical physics, and your broader oncology team. If you've been told a tumor is 'too large' or 'radioresistant' elsewhere, ask whether SFRT might be an option for you here.

## Learn More

[### SBRT

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[### Conditions Treated

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[### Clinical Data

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